Valproate for agitation in critically ill patients: A retrospective study

Valproate for agitation in critically ill patients: A retrospective study

The purpose was to describe the use of valproate therapy for agitation in critically ill patients, examine its safety, and describe its relationship with agitation and delirium. Valproate therapy was associated with a reduction in agitation, delirium, and concomitant psychoactive medication use within 48 hours of initiation.

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