Sedation Intensity in the First 48 Hours of Mechanical Ventilation and 180-Day Mortality: A Multinational Prospective Longitudinal Cohort Study

The management of pain, agitation, sedation, delirium, and mobilization represents a major challenge in the care of critically ill patients. Guidelines and best practice recommendations have been proposed to provide guidance to clinicians on their management. These recommendations, however, are based on studies reporting potential benefits in relation to short-term endpoints, such as ventilation time and ICU length of stay, rather than patient-centered endpoints such as long-term survival.

Crit Care Med. 2018 Jun;46(6):850-859. doi: 10.1097/CCM.0000000000003071