Angiotensin II for the Treatment of Vasodilatory Shock

Shock is a life-threatening syndrome characterized by decreased organ perfusion that can progress to irreversible organ failure. Vasodilatory shock is the most common type of shock and is characterized by peripheral vasodilation and reduced blood pressure despite preserved cardiac output. Vasodilatory shock requires immediate treatment to ensure organ perfusion by restoring adequate blood pressure while the underlying cause of shock is identified and treated. Vasopressors are used when IV fluid resuscitation alone fails to restore blood pressure. Patients with severe vasodilation with hypotension despite the use of high doses of vasopressors have a poor prognosis, with 30-day all-cause mortality exceeding 50%.

N Engl J Med 2017; 377:419-430. DOI: 10.1056/NEJMoa1704154